MozartV1, France, Analysis, bibRecord, 000127

Cloning and initial characterization of human and mouse Spot 14 genes

Identifieur interne : 000127 ( France/Analysis ); précédent : 000126; suivant : 000128

Cloning and initial characterization of human and mouse Spot 14 genes

Auteurs : Joël-Paul Grillasca [France] ; Marguerite Gastaldi [France] ; Hacène Khiri [France] ; Alexandra Dace [France] ; Nicole Peyrol [France] ; Pascal Reynier [France] ; Janine Torresani [France] ; Richard Planells [France]

Source :

FEBS Letters [ 0014-5793 ] ; 1996.

RBID : ISTEX:F96F02A27B61E9796B7481F75296AE5B9825617A

Abstract

The intricate regulation of Spot 14 expression in rat lipogenic tissues has provided a useful tool in studying nutritional and hormonal factors involved in transcription. To gain insight into its function and its possible involvement in human lipid disorders, we cloned human and mouse Spot 14 genes that shared with the rat gene a strong homology concerning the deduced amino acid sequence (81 and 94%, respectively) as well as the promoter region. The mouse promoter was characterized by transfection studies, while quantitative RT-PCR and in situ hybridization experiments showed that Spot 14 is expressed in human liver and, at a high level, in multiple symmetric lipomatosis nodules.

Url:

https://api.istex.fr/document/F96F02A27B61E9796B7481F75296AE5B9825617A/fulltext/pdf

DOI: 10.1016/S0014-5793(96)01433-0

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000871
to stream Istex, to step Curation: 000704
to stream Istex, to step Checkpoint: 002967
to stream Main, to step Merge: 003283
to stream Main, to step Curation: 003197
to stream Main, to step Exploration: 003197
to stream France, to step Extraction: 000127

Links to Exploration step

ISTEX:F96F02A27B61E9796B7481F75296AE5B9825617A

Le document en format XML

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<author><name sortKey="Grillasca, Joel Paul" sort="Grillasca, Joel Paul" uniqKey="Grillasca J" first="Joël-Paul" last="Grillasca">Joël-Paul Grillasca</name>
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<author><name sortKey="Gastaldi, Marguerite" sort="Gastaldi, Marguerite" uniqKey="Gastaldi M" first="Marguerite" last="Gastaldi">Marguerite Gastaldi</name>
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<author><name sortKey="Khiri, Hacene" sort="Khiri, Hacene" uniqKey="Khiri H" first="Hacène" last="Khiri">Hacène Khiri</name>
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<author><name sortKey="Dace, Alexandra" sort="Dace, Alexandra" uniqKey="Dace A" first="Alexandra" last="Dace">Alexandra Dace</name>
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<author><name sortKey="Peyrol, Nicole" sort="Peyrol, Nicole" uniqKey="Peyrol N" first="Nicole" last="Peyrol">Nicole Peyrol</name>
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<author><name sortKey="Reynier, Pascal" sort="Reynier, Pascal" uniqKey="Reynier P" first="Pascal" last="Reynier">Pascal Reynier</name>
</author>
<author><name sortKey="Torresani, Janine" sort="Torresani, Janine" uniqKey="Torresani J" first="Janine" last="Torresani">Janine Torresani</name>
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<author><name sortKey="Planells, Richard" sort="Planells, Richard" uniqKey="Planells R" first="Richard" last="Planells">Richard Planells</name>
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<front><div type="abstract" xml:lang="en">The intricate regulation of Spot 14 expression in rat lipogenic tissues has provided a useful tool in studying nutritional and hormonal factors involved in transcription. To gain insight into its function and its possible involvement in human lipid disorders, we cloned human and mouse Spot 14 genes that shared with the rat gene a strong homology concerning the deduced amino acid sequence (81 and 94%, respectively) as well as the promoter region. The mouse promoter was characterized by transfection studies, while quantitative RT-PCR and in situ hybridization experiments showed that Spot 14 is expressed in human liver and, at a high level, in multiple symmetric lipomatosis nodules.</div>
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Cloning and initial characterization of human and mouse Spot 14 genes

Cloning and initial characterization of human and mouse Spot 14 genes

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri